""   --
Cloned Meat? The french say no.
[ 13:20:33, Thursday, January 17 2008 ]
I've been hearing a great deal about what is evidently an up-and-coming controversy, that of the use of cloned animals in meat and milk production. Today the French government, world-renowed for its bravery and acceptance of new things, has cast in its lot: (these are the words of their agricultural minister)

I think there are ethical problems and problems of social acceptability and we are not going to start copying the American model...

Ahh, the french. Always doing things differently because they can't do it the same way as those filthy bourgeois americans.

Instead of relying on rhetoric to do my dirty work, let's look at the facts behind cloned meat and milk (which, incidentally, is still several years off by most accounts):

First off, Don't let the word "cloned" fool you. As I've stated on my blog several times, just because something is cloned should hardly cause one to bat an eyebrow. Identical twins, for example, are clones of each other. (I've always said the only thing that could be better than Beth would to have Beth twins, but I digress...) A clone is an exact genetic copy of another creature, sometimes achieved through genetic engineering.

Let's take a step back. The term "genetic engineering" is incredibly broad, and much abused. It can refer to a breeder crossing and re-crossing rose plants in his hothouse to generate a specific desired shade. It can be a milk producer selecting cows based on their milk production. Exotically, it can be a laboratory worker moving genes between species. Or, rather mundanely, it can be a laboratory worker generating a clone of a given animal.

Cloned animals are used for a very specific reason, and that's to preserve a desired trait. If you're a milk producer, you've likely used the previous definition of genetic engineering to select for only the best milk-producing cows you can. After all, why would you want anything less? The problem arises is that every now and then, even though you mate a cow who is a great milk producer with a bull who has produced great milkers, you'll get a dud. Mating and raising a calf to maturity, only to discover that it isn't the star you hoped it'd be costs a lot of cash. There's already quite the market for proven bull semen, as any look at a breeder's catalog will tell you. It's like printing money, once you find that primo bull.

Wouldn't it be great, then, if you could make a copy of your best milk producer? That is, in its entirety, is what cloning is. For beef producers, you simply clone your beefiest steers over and over. Got a chicken that lays a dozen eggs a day? Forget golden eggs, just clone that sucker! There's no magic, there's no cross species genes, they're just copies of each other, a whole feedlot of identical twins.

Of course, there are drawbacks. The problem with having a multitude of identical genetic stock is that in nature, genetic variability is the basis for survival. It's the very bedrock of natural selection. In a naturally-occurring herd, it is very possible that a disease might come along that would kill 90% of the herd, but because of genetic variation, 10% will survive to go on and preserve their genes. In a genetically identical environment the whole herd will probably bite the dust.

Now, the average herds we get our meat and milk from are already very similar genetically, and bear little resemblance to what would be a "naturally occurring" herd anyway. Most of our milk and meat producers already live in very stringently-controlled environments which bear little resemblance to their natural habitats. (Mike reminds me that corn, their primary foodstuff, isn't even usually a part of their natural diet!) This is hardly optimal, of course, but it does allow for big mac and inexpensive protein that would otherwise be inaccessible for us po' folk.

What you really need to do is take a step back and see who both benefits and who stands to lose something through the introduction of cloned animals. The payoffs are obvious for those who use cloned animals. The main corporations that stand to lose from their introduction is boutique producers and professional breeders. These are the individuals who will use unscientific rhetoric and scaretactics to rally ignorant consumers.

You, however, are not ignorant, especially if you keep abreast with what the terms and underlying science is. Hope this has been informative, let me know if you have questions.
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Since I have neither an operating crystal ball (it broke last week) nor a time machine, I have no idea how cloning will be incorporated into future societies. But it seems to be that even if the vast majority of the animals or plants of the future were clones of the highest producers, there would be some reservoir of at least the DNA from other stock. Because, for one thing, what we currently value as the "best" in cattle or corn might not be valued as the "best" later on.
And I wonder how many areas of life people would be willing to sacrifice variety for efficiency.
Besides, who would determine what is "best"? Could we all agree on what the "best" example of every life form is? So many areas of human life are influenced by capricious taste, not hardened practicality. Is there really a housecat that could satisfy everyone? Could we ever decide which flower is best -- orchids, roses, or lilies? Is there really any man or woman so perfect that only their clones should be perpetuated?
Hannah
00:46:03, 01/28/08
(5)
As a producer i think that you touched on the primary problem, disease. As it is disease issues can cause alot of havoc. I remain a skeptic... besides it wouldnt be very fun for every one to lool alike, call me old fashioned.
Andrew
20:38:27, 01/27/08
(5)
As I mentioned in the article though, genetics is wily enough that you can mate a prize heifer and a prize bull, and still get a mediocre performer. Better to pick the cream of the crop and copy the heck out of it. Carry those embryos in scrubs, if you will, but this will be the way it's done in the future.
Elihu
12:50:07, 01/18/08
(5)
A far cheaper way to get what you describe is to use "scrub" cows to carry to term "artificially" inseminated embryos. Take a whole bunch of eggs from prize cows and fertilize them with prize sperm and you have a prize herd. That is happening successfully. Ask Aunt Mary.
InIhms
11:21:16, 01/18/08
(5)
"Perhaps We Could Call It a Fraternal Clone
FDA's approval of cloned animal products doesn't factor in epigenetic idiosyncracies, says a blogger."

This statement was on the Genome Technology Online daily scan. I also found that "nuclear transfer is still a very inefficient process (2%)."

From what I read they still are not sure what is causing the premature aging- telemere degradation was ruled out in an article I read on INNOVITA. They do not know the extent of the "The ends of eukaryotic chromosomes are capped with copies of a hexamer repeat sequence and associated proteins. These structures are known as telomeres. Telomeres stabilize the ends of chromosomes during replication. The DNA polymerases that replicate eukaryotic chromosomes use an 8- to 12-base stretch of RNA to prime DNA synthesis. As a consequence, after DNA replication, one end of a linear chromosome will be replicated to the very end, whereas the other end will have a short 8- to 12-base gap generated by removal of the RNA primer. Because a conventional DNA polymerase cannot fill in this gap, in every subsequent cell division a given DNA end will be incompletely replicated."
InIhms
11:17:12, 01/18/08
(5)
Good questions John.

You have valid concerns on both points. Currently, it's quite expensive to clone animals, but technology in the area is racing forward. As far as I can tell, it will be several years before it make complete business sense, but definitely within this decade.

The more technical problems concerning cloning itself are also of particular concern. There were problems with some of the earliest attempts (Dolly, etc.), but I believe most of the metagenomic problems concerning clone aging (telomere degradation for example) have been taken care of.
Elihu
19:32:16, 01/17/08
(5)
Have we reached the point, however, where it is cheaper to clone x-number of cattle, rather than footing the cost of a "dud" every x-number of cattle? I haven't heard much talk yet of frugal cloning... just expensive cloning.

Also, are there problems involving genetic material life span. For example, as biological life forms age, is there any permanent damage done to the instruction sets, thereby making cloning an uphill battle against entropy?

My question right now isn't that cloning is somehow violating nature (as you said, twins are clones too), but whether it's a line of research that's going to return dividends proportionate to the money going into it. I can only assume that side projects (well beyond the simplistic 1 good cow = 10 good cows) could prove worthwhile, so perhaps the direct end result isn't the point at all.

What are your thoughts on this, or have I missed some major plot twists and am now just inconveniencing large amounts of electrons?
Iaian7
18:33:38, 01/17/08
(5)
Well put, sir.
Wife at Work
17:14:52, 01/17/08
(5)
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